SMAC-mediated apoptotic response

Stable Identifier
R-HSA-111469
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Once released from the mitochondria, SMAC binds to IAP family proteins displacing them from Caspase:IAP complexes liberating the active caspases.

Literature References
PubMed ID Title Journal Year
15077149 Toxic proteins released from mitochondria in cell death Oncogene 2004
Participants
Participant Of
Orthologous Events