Reactome: A Curated Pathway Database

Apoptotic factor-mediated response

Stable Identifier
R-HSA-111471
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

In response to apoptotic signals, mitochondrial proteins are released into the cytosol and activate both caspase-dependent and -independent cell death pathways. Cytochrome c induces apoptosome formation, AIF and endonuclease G function in caspase independent apoptotic nuclear DNA damage. Smac/DIABLO and HtrA2/OMI both promote caspase activation and caspase-independent cytotoxicity (Saelens et al., 2004).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
Orthologous Events