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Opioid Signalling

Stable Identifier
R-HSA-111885
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Opioids are chemical substances similar to opiates, the active substances found in opium (morphine, codeine etc.). Opioid action is mediated by the receptors for endogenous opioids; peptides such as the enkephalins, the endorphins or the dynorphins. Opioids possess powerful analgesic and sedative effects, and are widely used as pain-killers. Their main side-effect is the rapid establishment of a strong addiction. Opioids receptors are G-protein coupled receptors (GPCR). There are four classes of receptors: mu (MOR), kappa (KOR) and delta (DOR), and the nociceptin receptor (NOP).

Literature References
PubMed ID Title Journal Year
9218123 G proteins and opioid receptor-mediated signalling Cell Signal 1997
16612131 Signal transduction induced by opioids in immune cells: a review Neuroimmunomodulation 2006
9422713 The many faces of G protein signaling J Biol Chem 1998
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