Reactome: A Curated Pathway Database

cAMP induces dissociation of inactive PKA tetramers

Stable Identifier
R-HSA-111925
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The four protein kinase A (PKA) regulatory subunit isoforms differ in their tissue specificity and functional characteristics. The specific isoform activated in response to glucagon signalling is not known. The PKA kinase is a tetramer of two regulatory and two catalytic. The regulatory subunits block the catalytic subunits. Binding of cAMP to the regulatory subunit leads to the dissociation of the tetramer into two active dimers made up of a regulatory and a catalytic subunit.

Literature References
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Orthologous Events