Reactome: A Curated Pathway Database

cAMP induces dissociation of inactive PKA tetramers (R-HSA-111925)

Species Homo sapiens

Summation

The four protein kinase A (PKA) regulatory subunit isoforms differ in their tissue specificity and functional characteristics. The specific isoform activated in response to glucagon signalling is not known. The PKA kinase is a tetramer of two regulatory and two catalytic. The regulatory subunits block the catalytic subunits. Binding of cAMP to the regulatory subunit leads to the dissociation of the tetramer into two active dimers made up of a regulatory and a catalytic subunit.

Locations in the PathwayBrowser
Immune System(Homo sapiens)
Signal Transduction(Homo sapiens)
Transmembrane transport of small molecules(Homo sapiens)
Metabolism(Homo sapiens)
Additional Information
Compartment cytosol
Literature References
pubMedId Title Journal Year
16407073 Dynamic binding of PKA regulatory subunit RI alpha Structure 2006