Reactome: A Curated Pathway Database

PKA-mediated phosphorylation of CREB (R-HSA-111931)

Species Homo sapiens


Cyclic adenosine 3',5'-monophosphate (cAMP) induces gene transcription through activation of cAMP-dependent protein kinase (PKA), and subsequent phosphorylation of the transcription factor cAMP response element-binding protein, CREB, at serine-133.

Locations in the PathwayBrowser
Immune System(Homo sapiens)
Signal Transduction(Homo sapiens)

Additional Information
Compartment plasma membrane , nucleoplasm , cytosol
Literature References
pubMedId Title Journal Year
15337521 What turns CREB on? Cell Signal 2004
16125054 The cAMP signalling pathway activates CREB through PKA, p38 and MSK1 in NIH 3T3 cells Cell Signal 2005