Reactome: A Curated Pathway Database

CaMK IV-mediated phosphorylation of CREB (R-HSA-111932) [Homo sapiens]


The Ca2+-calmodulin-dependent protein kinase (CaM kinase) cascade includes three kinases: CaM-kinase kinase (CaMKK); and the CaM kinases CaMKI and CaMKIV, which are phosphorylated and activated by CaMKK. Members of this cascade respond to elevation of intracellular Ca2+ levels. CaMKK and CaMKIV localize both to the nucleus and to the cytoplasm, whereas CaMKI is only cytosolic. Nuclear CaMKIV regulates transcription through phosphorylation of several transcription factors, including CREB. In the cytoplasm, there is extensive cross-talk between CaMKK, CaMKIV and other signaling cascades, including those that involve the cAMP-dependent kinase (PKA), MAP kinases and protein kinase B (PKB/Akt).

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm , cytosol
Cross References
Database Identifier
BioModels Database BIOMD0000000468, BIOMD0000000088, BIOMD0000000467
Literature References
pubMedId Title Journal Year
10366852 The Ca-calmodulin-dependent protein kinase cascade Trends Biochem Sci 1999