Reactome: A Curated Pathway Database

Ca-dependent events (R-HSA-111996) [Homo sapiens]


Calcium, as the ion Ca2+, is essential in many biological processes. The majority of Ca2+ in many organisms is bound to phosphates which form skeletal structures and also buffer Ca2+ levels in extracellular fluids (typically 1 millimolar). Intracellular free Ca2+, by contrast, is 10,000 times lower than the outside of the cell (typically 10 micromolar). This concentration gradient is used to import Ca2+ into cells where it acts as a second messenger.

Literature References
pubMedId Title Journal Year
17697045 IP3 receptor/Ca2+ channel: from discovery to new signaling concepts J Neurochem 2007
16076488 Calcium signalling: past, present and future Cell Calcium 2005
11162741 Calcium signalling--an overview Semin Cell Dev Biol 2001
18083096 Calcium signaling Cell 2007