Ca-dependent events

Stable Identifier
R-HSA-111996
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Calcium, as the ion Ca2+, is essential in many biological processes. The majority of Ca2+ in many organisms is bound to phosphates which form skeletal structures and also buffer Ca2+ levels in extracellular fluids (typically 1 millimolar). Intracellular free Ca2+, by contrast, is 10,000 times lower than the outside of the cell (typically 10 micromolar). This concentration gradient is used to import Ca2+ into cells where it acts as a second messenger.

Literature References
PubMed ID Title Journal Year
16076488 Calcium signalling: past, present and future

Petersen, OH, Michalak, M, Verkhratsky, A

Cell Calcium 2005
18083096 Calcium signaling

Clapham, DE

Cell 2007
17697045 IP3 receptor/Ca2+ channel: from discovery to new signaling concepts

Mikoshiba, K

J Neurochem 2007
11162741 Calcium signalling--an overview

Bootman, MD, Collins, TJ, Peppiatt, CM, Prothero, LS, MacKenzie, L, De Smet, P, Travers, M, Tovey, SC, Seo, JT, Berridge, MJ, Ciccolini, F, Lipp, P

Semin Cell Dev Biol 2001
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