Reactome: A Curated Pathway Database

PLC beta mediated events (R-HSA-112043)

Species Homo sapiens

Summation

The phospholipase C (PLC) family of enzymes is both diverse and complex. The isoforms beta, gamma and delta (each have subtypes) make up the members of this family. PLC hydrolyzes phosphatidylinositol bisphosphate (PIP2) into two second messengers, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 mobilizes intracellular calcium stores while DAG activates protein kinase C isoforms which are involved in regulatory functions.

Locations in the PathwayBrowser
Cross References
Database Identifier
BioModels Database BIOMD0000000088