Reactome: A Curated Pathway Database

Neurotransmitter Release Cycle (R-HSA-112310)

Species Homo sapiens


Neurotransmitter is stored in the synaptic vesicle in the pre-synaptic terminal prior to its release in the synaptic cleft upon depolarization of the pre-synaptic membrane. The release of the neurotransmitter is a multi-step process that is controlled by electrical signals passing through the axons in form of action potential. Neurotransmitters include glutamate, acetylcholine, nor-epinephrine, dopamine and seratonin. Each of the neurotransmitter cycle is independently described.

Locations in the PathwayBrowser
Additional Information
GO Biological Process neurotransmitter secretion (0007269)
Literature References
pubMedId Title Journal Year
17880890 The neurotransmitter cycle and quantal size Neuron 2007
16819626 Vesicle pools, docking, priming, and release Cell Tissue Res 2006
15217342 The synaptic vesicle cycle Annu Rev Neurosci 2004
16865347 Molecular organization of the presynaptic active zone Cell Tissue Res 2006