Reactome: A Curated Pathway Database
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Neurotransmitter Release Cycle

Stable Identifier
R-HSA-112310
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Neurotransmitter is stored in the synaptic vesicle in the pre-synaptic terminal prior to its release in the synaptic cleft upon depolarization of the pre-synaptic membrane. The release of the neurotransmitter is a multi-step process that is controlled by electrical signals passing through the axons in form of action potential. Neurotransmitters include glutamate, acetylcholine, nor-epinephrine, dopamine and seratonin. Each of the neurotransmitter cycle is independently described.

Literature References
PubMed ID Title Journal Year
16865347 Molecular organization of the presynaptic active zone Cell Tissue Res 2006
17880890 The neurotransmitter cycle and quantal size Neuron 2007
15217342 The synaptic vesicle cycle Annu Rev Neurosci 2004
16819626 Vesicle pools, docking, priming, and release Cell Tissue Res 2006
Participants
Participant Of
Orthologous Events