Reactome: A Curated Pathway Database
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Hypophosphorylation of RNA Pol II CTD by FCP1P protein

Stable Identifier
R-HSA-112383
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

FCP1 dephosphorylates RNAP II in ternary elongation complexes as well as in solution and is thought to function in the recycling of RNAP II during the transcription cycle. Biochemical experiments suggest that human FCP1 targets CTDs that are phosphorylated at serine 2 (CTD-serine 2) and/or CTD-serine 5. It is also observed to stimulate elongation independent of its catalytic activity. Dephosphorylation of Ser2 - phosphorylated Pol II results in hypophosphorylated form that disengages capping enzymes (CE).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
phosphoprotein phosphatase activity of CTDP1 [nucleoplasm] CTDP1 [nucleoplasm] phosphoprotein phosphatase activity (0004721)
Orthologous Events