Reactome: A Curated Pathway Database

Hypophosphorylation of RNA Pol II CTD by FCP1P protein (R-HSA-112383) [Homo sapiens]


FCP1 dephosphorylates RNAP II in ternary elongation complexes as well as in solution and is thought to function in the recycling of RNAP II during the transcription cycle. Biochemical experiments suggest that human FCP1 targets CTDs that are phosphorylated at serine 2 (CTD-serine 2) and/or CTD-serine 5. It is also observed to stimulate elongation independent of its catalytic activity. Dephosphorylation of Ser2 - phosphorylated Pol II results in hypophosphorylated form that disengages capping enzymes (CE).

Additional Information
Compartment nucleoplasm
Catalyst Activity
PhysicalEntity Activity Active Units
CTDP1 phosphoprotein phosphatase activity (0004721)