Reactome: A Curated Pathway Database

RNA Polymerase III Termination and release of transcribed RNA (R-HSA-113454) [Homo sapiens]


Efficient transcript production requires efficient release of RNA polymerase at the terminator; slow release at the terminator of a short transcription unit quickly becomes rate limiting for transcription at steady state. Although pol III autonomously recognizes sequence terminators, proteins that help to rapidly detach pol III from the terminator can affect the productivity of transcription if they eliminate termination as the rate-limiting step.

La, NF1 family proteins, PC4 and topoisomerase I have been proposed as accessory pol III transcription factors that facilitate multi-cycle transcription by hspol III, and are hence described as positive regulators of termination.

Additional Information
Compartment nucleoplasm
GO Biological Process termination of RNA polymerase III transcription (0006386)
This entry is regulated by
Regulation type Name