Efficient transcript production requires efficient release of RNA polymerase at the terminator; slow release at the terminator of a short transcription unit quickly becomes rate limiting for transcription at steady state. Although pol III autonomously recognizes sequence terminators, proteins that help to rapidly detach pol III from the terminator can affect the productivity of transcription if they eliminate termination as the rate-limiting step.
La, NF1 family proteins, PC4 and topoisomerase I have been proposed as accessory pol III transcription factors that facilitate multi-cycle transcription by hspol III, and are hence described as positive regulators of termination.
|GO Biological Process||termination of RNA polymerase III transcription (0006386)|
|8035818||La proteins from Drosophila melanogaster and Saccharomyces cerevisiae: a yeast homolog of the La autoantigen is dispensable for growth.||Mol Cell Biol||1994|
|9660958||DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination and transcription reinitiation by RNA polymerase III.||Mol Cell||1998|
|11118217||Nuclear factor 1 (NF1) affects accurate termination and multiple-round transcription by human RNA polymerase III.||EMBO J||2001|
|8308883||Analysis of RNA chain elongation and termination by Saccharomyces cerevisiae RNA polymerase III.||J Mol Biol||1994|