Reactome: A Curated Pathway Database

E2F mediated regulation of DNA replication (R-HSA-113510)

Species Homo sapiens


Progression through G1 and G1 to S-phase transition that initiates DNA synthesis involve many complexes that are regulated by RB1:E2F pathway. RB1:E2F pathway plays a key role in gene expression regulation in proliferating and differentiated cells. As a repressor, E2F remains bound to RB1; it can activate the expression of S-phase genes involved in DNA replication after the phosphorylation of RB1.
E2F proteins regulate expression of genes involved in various processes thereby forming interlinks between cell cycle, DNA synthesis, DNA damage recognition etc.
In this module, activation of replication related genes by E2F1 and two ways by which E2F1 regulates DNA replication initiation are annotated. Detailed connection between the E2F protein function and various pathways will be covered in future releases of Reactome.

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm
Literature References
pubMedId Title Journal Year
12393009 G(1) to S transition: more than a cell cycle engine switch. Curr Opin Plant Biol 2002
12473340 A revised picture of the E2F transcriptional network and RB function. Curr Opin Cell Biol 2002
12726857 Emerging roles for E2F: beyond the G1/S transition and DNA replication. Cancer Cell 2003