Activation, translocation and oligomerization of BAX

Stable Identifier
R-HSA-114294
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Activation, translocation and oligomerization of BAX
Click the image above or here to open this pathway in the Pathway Browser
As a result of binding to Bid, Bax oligomerizes and integrates in the outer mitochondrial membrane, triggering cytochrome c release. Bax mitochondrial membrane insertion triggered by Bid may represent a key step in pathways leading to apoptosis (Eskes et al., 2000).
Literature References
PubMed ID Title Journal Year
11136736 Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells.

Martinou, JC, Antonsson, B, Montessuit, S, Sanchez, B

J Biol Chem 2001
12193163 Bax oligomerization in mitochondrial membranes requires tBid (caspase-8-cleaved Bid) and a mitochondrial protein

Roucou, X, Martinou, JC, Antonsson, B, Montessuit, S

Biochem J 2002
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway (1901030)
Orthologous Events
Activation, translocation and oligomerization of BAX (Bos taurus)
Activation, translocation and oligomerization of BAX (Canis familiaris)
Activation, translocation and oligomerization of BAX (Danio rerio)
Activation, translocation and oligomerization of BAX (Mus musculus)
Activation, translocation and oligomerization of BAX (Rattus norvegicus)
Activation, translocation and oligomerization of BAX (Sus scrofa)
Cross References
BioModels Database
Created
Hardwick, JM  (2004-08-09)
Tsujimoto, Y  (2004-08-09)
Cite Us!