Reactome: A Curated Pathway Database

Activation, translocation and oligomerization of BAX

Stable Identifier
R-HSA-114294
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

As a result of binding to Bid, Bax oligomerizes and integrates in the outer mitochondrial membrane, triggering cytochrome c release. Bax mitochondrial membrane insertion triggered by Bid may represent a key step in pathways leading to apoptosis (Eskes et al., 2000).

Literature References
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database