Reactome: A Curated Pathway Database

Downstream signaling events of B Cell Receptor (BCR) (R-HSA-1168372)

Species Homo sapiens


Second messengers (calcium, diacylglycerol, inositol 1,4,5-trisphosphate, and phosphatidyinositol 3,4,5-trisphosphate) trigger signaling pathways: NF-kappaB is activated via protein kinase C beta, RAS via RasGRP proteins, NF-AT via calcineurin, and AKT via PDK1 (reviewed in Shinohara and Kurosaki 2009, Stone 2006).

Locations in the PathwayBrowser
Additional Information
Compartment cytosol , nucleoplasm
Literature References
pubMedId Title Journal Year
19909372 Comprehending the complex connection between PKCbeta, TAK1, and IKK in BCR signaling Immunol Rev 2009
17052215 Regulation of Ras in lymphocytes: get a GRP Biochem Soc Trans 2006