Reactome: A Curated Pathway Database

Prolactin receptor is internalized (R-HSA-1170539) [Homo sapiens]

Black Box Event

PRLR is regulated by ubiquitination of the activated receptor, leading to lysosomal degradation (Djiane et al. 1981, 1982, Lu et al. 2002). Recruitment of the SCFbeta-TrCP ubiquitin ligase complex enables receptor ubiquitination and internalization (Li et al. 2004). This limits the duration and intensity of receptor signaling. Deregulation of this negative control lead to pathological conditions including cancer (Swaminathan et al. 2008).

Additional Information
Compartment plasma membrane , cytosol
Literature References
pubMedId Title Journal Year
15082796 Negative regulation of prolactin receptor stability and signaling mediated by SCF(beta-TrCP) E3 ubiquitin ligase Mol Cell Biol 2004