Reactome: A Curated Pathway Database

Prolactin receptor is internalized

Stable Identifier
R-HSA-1170539
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

PRLR is regulated by ubiquitination of the activated receptor, leading to lysosomal degradation (Djiane et al. 1981, 1982, Lu et al. 2002). Recruitment of the SCFbeta-TrCP ubiquitin ligase complex enables receptor ubiquitination and internalization (Li et al. 2004). This limits the duration and intensity of receptor signaling. Deregulation of this negative control lead to pathological conditions including cancer (Swaminathan et al. 2008).

Literature References
Participants
Participant Of
Orthologous Events