Reactome: A Curated Pathway Database

Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus (R-HSA-1176059)

Species Homo sapiens


Influenza A virus nonstructural protein 1 (NS1A) is a multifunctional protein that exists as a dimer and is involved in the inhibition of host cell antiviral pre-mRNA processing and counteracts host cell antiviral responses. Unlike most other RNA viruses, influenza viruses replicate in the nucleus of the host cells. NS1A protein carries two nuclear localization signal (NLS) elements and these sequence elements are recognized by importin-alpha/beta. In the cytoplasm NS1A binds to importin-alpha/beta and these protein complexes are then translocated into the nucleus through the nuclear pore complex (NPC). Note:Reactions directly involving interactions of human host proteins with foreign ones are highlighted in red.

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm , cytosol
GO Biological Process intracellular transport of virus (0075733)
Catalyst Activity
PhysicalEntity Activity Active Units
Nuclear Pore Complex (NPC) nucleocytoplasmic transporter activity (0005487)
This entry is regulated by
Regulation type Name