Reactome: A Curated Pathway Database

Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

Influenza A virus nonstructural protein 1 (NS1A) is a multifunctional protein that exists as a dimer and is involved in the inhibition of host cell antiviral pre-mRNA processing and counteracts host cell antiviral responses. Unlike most other RNA viruses, influenza viruses replicate in the nucleus of the host cells. NS1A protein carries two nuclear localization signal (NLS) elements and these sequence elements are recognized by importin-alpha/beta. In the cytoplasm NS1A binds to importin-alpha/beta and these protein complexes are then translocated into the nucleus through the nuclear pore complex (NPC). Note:Reactions directly involving interactions of human host proteins with foreign ones are highlighted in red.

Literature References
Participant Of
This entity is regulated by:
Title Physical Entity Activity
nucleocytoplasmic transporter activity of Nuclear Pore Complex (NPC) [nuclear envelope] Nuclear Pore Complex (NPC) [nuclear envelope] nucleocytoplasmic transporter activity (0005487)
Name Identifier Synonyms
influenza 8469 [Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation]