Reactome: A Curated Pathway Database

Meiotic synapsis (R-HSA-1221632)

Species Homo sapiens

Summation

Meiotic synapsis is the stable physical pairing of homologous chromosomes that begins in leptonema of prophase I and lasts until anaphase of prophase I. First, short segments of axial elements form along chromosomes. Telomeres then cluster at a region of the inner nuclear membrane and axial elements extend and fuse along the length of the chromosomes. Subsequent to the initiation of recombination transverse filaments of SYCP1 link axial/lateral elements to a central element containing SYCE1 and SYCE2, thus forming the synaptonemal complex (reviewed in Yang and Wang 2009).
Unsynapsed regions are silenced during pachynema by recruitment of BRCA1 and ATR, which phosphorylates histone H2AX (reviewed in Inagaki et al. 2010).

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm , nuclear envelope
Literature References
pubMedId Title Journal Year
20364103 DNA double strand break repair, chromosome synapsis and transcriptional silencing in meiosis Epigenetics 2010
18948708 The Mammalian synaptonemal complex: a scaffold and beyond Genome Dyn 2009