Reactome: A Curated Pathway Database

Phagosomal maturation (early endosomal stage) (R-HSA-1222556)

Species Homo sapiens

Summation

Alveolar macrophages normally develop their phagosome along the endolysosomal pathway. However, after having internalized Mtb, this development is arrested at an early stage and only includes acidification, nitric oxide and superoxide production, as well as the use of a few other proteins that can be gained from other endosomes which still can interact with the phagosome (Flannagan et al. 2009).

Locations in the PathwayBrowser
Additional Information
GO Biological Process phagosome maturation (0090382)
Diseases
Name Identifier Synonyms
tuberculosis 399 [tuberculous abscess, Tuberculoma (finding), tuberculoma]
Literature References
pubMedId Title Journal Year
19369951 Antimicrobial mechanisms of phagocytes and bacterial evasion strategies Nat Rev Microbiol 2009