Alveolar macrophages normally develop their phagosome along the endolysosomal pathway. However, after having internalized Mtb, this development is arrested at an early stage and only includes acidification, nitric oxide and superoxide production, as well as the use of a few other proteins that can be gained from other endosomes which still can interact with the phagosome (Flannagan et al. 2009).
|GO Biological Process||phagosome maturation (0090382)|
|tuberculosis||399||[tuberculous abscess, Tuberculoma (finding), tuberculoma]|
|19369951||Antimicrobial mechanisms of phagocytes and bacterial evasion strategies||Nat Rev Microbiol||2009|