Reactome: A Curated Pathway Database

Regulation of gene expression by Hypoxia-inducible Factor (R-HSA-1234158) [Homo sapiens]


HIF-alpha (HIF1A, HIF2A (EPAS1), HIF3A) is translocated to the nucleus, possibly by two pathways: importin 4/7 (Chachami et al. 2009) and importin alpha/beta (Depping et al. 2008). Once in the nucleus HIF-alpha heterodimerizes with HIF-beta (ARNT) (Wang et al. 1995, Jiang et al. 1996, Tian et al. 1997, Gu et al. 1998, Erbel et al. 2003) and recruits CBP and p300 to promoters of target genes (Ebert and Bunn 1998, Kallio et al. 1998, Ema et al. 1999, Gu et al. 2001, Dames et al. 2002, Freedman et al. 2002).

Additional Information
Compartment nucleoplasm
Cross References
Database Identifier
BioModels Database BIOMD0000000300
Literature References
pubMedId Title Journal Year
19788888 Transport of hypoxia-inducible factor HIF-1alpha into the nucleus involves importins 4 and 7 Biochem Biophys Res Commun 2009
9822602 Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha EMBO J 1998
18187047 Nuclear translocation of hypoxia-inducible factors (HIFs): involvement of the classical importin alpha/beta pathway Biochim Biophys Acta 2008
9000051 Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells Genes Dev 1997
8663540 Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1 J Biol Chem 1996
7539918 Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension Proc Natl Acad Sci U S A 1995
14668441 Structural basis for PAS domain heterodimerization in the basic helix--loop--helix-PAS transcription factor hypoxia-inducible factor Proc Natl Acad Sci U S A 2003
9840812 Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha Gene Expr 1998
10202154 Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300 EMBO J 1999
11959977 Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response Proc Natl Acad Sci U S A 2002
11959990 Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha Proc Natl Acad Sci U S A 2002
11063749 Molecular mechanism of hypoxia-inducible factor 1alpha -p300 interaction. A leucine-rich interface regulated by a single cysteine J Biol Chem 2001
9632793 Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein Mol Cell Biol 1998