Reactome: A Curated Pathway Database

Proteasome proteolyzes ub-HIF-alpha (R-HSA-1234159) [Homo sapiens]

Black Box Event

Destruction of ubiquitinated HIF-alpha can occur in both the cytosol and nucleus (Berra et al. 2001). Upon reoxygenation of hypoxic cells HIF-alpha is ubiquitinated in the nucleus and transported to the cytosol in a complex with VHL:ElonginB:ElonginC:CUL2:RBX1 where it is destroyed (Groulx and Lee 2002, Jaakkola et al. 2001, Ivan et al. 2001)

Additional Information
Compartment cytosol