Reactome: A Curated Pathway Database

Proteasome proteolyzes ub-HIF-alpha (R-HSA-1234159)

Species Homo sapiens


Destruction of ubiquitinated HIF-alpha can occur in both the cytosol and nucleus (Berra et al. 2001). Upon reoxygenation of hypoxic cells HIF-alpha is ubiquitinated in the nucleus and transported to the cytosol in a complex with VHL:ElonginB:ElonginC:CUL2:RBX1 where it is destroyed (Groulx and Lee 2002, Jaakkola et al. 2001, Ivan et al. 2001)

Locations in the PathwayBrowser
Additional Information
Compartment cytosol