Reactome: A Curated Pathway Database

Proteasome proteolyzes ub-HIF-alpha

Stable Identifier
R-HSA-1234159
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Destruction of ubiquitinated HIF-alpha can occur in both the cytosol and nucleus (Berra et al. 2001). Upon reoxygenation of hypoxic cells HIF-alpha is ubiquitinated in the nucleus and transported to the cytosol in a complex with VHL:ElonginB:ElonginC:CUL2:RBX1 where it is destroyed (Groulx and Lee 2002, Jaakkola et al. 2001, Ivan et al. 2001)

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
endopeptidase activity of 26S proteasome [cytosol] 26S proteasome [cytosol] endopeptidase activity (0004175)
Orthologous Events