HIF-alpha is translocated into the nucleus (Kallio et al. 1998, Depping et al. 2008, Chachami et al. 2009). Importin 4 and importin 7 (Chachami et al. 2009) as well as the importin alpha/beta pathway (Depping et al. 2008) appear to be capable of interacting with HIF-alpha. During hypoxia HIF-alpha accumulates in the nucleus where it associates with CBP and p300 (Kallio et al. 1998).
|19788888||Transport of hypoxia-inducible factor HIF-1alpha into the nucleus involves importins 4 and 7||Biochem Biophys Res Commun||2009|
|9822602||Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha||EMBO J||1998|
|18187047||Nuclear translocation of hypoxia-inducible factors (HIFs): involvement of the classical importin alpha/beta pathway||Biochim Biophys Acta||2008|