Formation of HIF:CBP:p300 complex at promoters (R-HSA-1234167) [Homo sapiens]

Black Box Event

HIF (heterodimer of HIF-alpha and HIF-beta) recruits p300 and CBP to the promoters of target genes (Kallio et al. 1998, Ebert and Bunn 1998, Ema et al. 1999, Gu et al. 2001, Dames et al. 2002, Freedman et al. 2002).

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Compartment nucleoplasm
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Literature References
pubMedId Title Journal Year
10202154 Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300 EMBO J 1999
9822602 Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha EMBO J 1998
11959977 Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response Proc Natl Acad Sci U S A 2002
11959990 Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha Proc Natl Acad Sci U S A 2002
11063749 Molecular mechanism of hypoxia-inducible factor 1alpha -p300 interaction. A leucine-rich interface regulated by a single cysteine J Biol Chem 2001
9632793 Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein Mol Cell Biol 1998
17804822 The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha Mol Biol Cell 2007
Inferred Entries
Orthologous events