Reactome: A Curated Pathway Database

ub-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol

Stable Identifier
R-HSA-1234175
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

When hypoxic cells return to normoxia, HIF-alpha is ubiquitinated in the nucleus and exported to the cytosol (Groulx and Lee 2002). The shuttling of VHL between the nucleus and cytosol is required (Groulx and Lee 2002, Lee et al. 1999).

Literature References
Participants
Participant Of
Orthologous Events