Cross-presentation of soluble exogenous antigens (endosomes)

Stable Identifier
R-HSA-1236978
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Exogenous soluble antigens are cross-presented by dendritic cells, albeit with lower efficiency than for particulate substrates. Soluble antigens destined for cross-presentation are taken up by distinct endocytosis mechanisms which route them into stable early endosomes and then to the cytoplasm for proteasomal degradation and peptide loading.

Literature References
PubMed ID Title Journal Year
17157489 Cross-talk between the endocytic pathway and the endoplasmic reticulum in cross-presentation by MHC class I molecules

Monu, N, Trombetta, ES

Curr Opin Immunol 2007
20171863 Intracellular mechanisms of antigen cross presentation in dendritic cells

Amigorena, S, Savina, A

Curr Opin Immunol 2010
15592474 Access of soluble antigens to the endoplasmic reticulum can explain cross-presentation by dendritic cells

Ackerman, AL, Kyritsis, C, Tampé, R, Cresswell, P

Nat Immunol 2005
Participants
Participant Of
Event Information
Orthologous Events
Authored
Reviewed