Reactome: A Curated Pathway Database

Cross-presentation of soluble exogenous antigens (endosomes)

Stable Identifier
R-HSA-1236978
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Exogenous soluble antigens are cross-presented by dendritic cells, albeit with lower efficiency than for particulate substrates. Soluble antigens destined for cross-presentation are taken up by distinct endocytosis mechanisms which route them into stable early endosomes and then to the cytoplasm for proteasomal degradation and peptide loading.

Literature References
Participants
Participant Of
Orthologous Events