Reactome: A Curated Pathway Database

Hemoglobin A binds oxygen and releases protons and carbon dioxide

Stable Identifier
R-HSA-1247668
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Haldane Effect
Locations in the PathwayBrowser
Summation

The binding of oxygen (O2) to hemoglobin (HbA) decreases the affinity of HbA for protons (H+) bound at histidine residues and carbon dioxide (CO2) bound chemically as a carbamate at the N-terminus of the HbA (Ferguson and Roughton 1934, Kernohan & Roughton 1968, Klocke 1973, Morrow et al. 1973, Morrow et al. 1976, Tazawa et al. 1983, Kraan & Rispens 1985, Doyle et al. 1987, Mertzlufft & Brandt 1989, Kalhoff et al.1994, Dash & Bassingthwaighte 2010, reviewed in Jensen 2004). This property of HbA is known as the Haldane Effect and facilitates the exchange of CO2 for O2 in the lungs.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
Orthologous Events