Reactome: A Curated Pathway Database

SHC1 events in ERBB4 signaling

Stable Identifier
R-HSA-1250347
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

All splicing isoforms of ERBB4 possess two tyrosine residues in the C-tail that serve as docking sites for SHC1 (Kaushansky et al. 2008, Pinkas-Kramarski et al. 1996, Cohen et al. 1996). Once bound to ERBB4, SHC1 becomes phosphorylated on tyrosine residues by the tyrosine kinase activity of ERBB4, which enables it to recruit the complex of GRB2 and SOS1, resulting in the guanyl-nucleotide exchange on RAS and activation of RAF and MAP kinase cascade (Kainulainen et al. 2000).

Participants
Participant Of
Orthologous Events
Cross References