Reactome: A Curated Pathway Database

PLCG1 events in ERBB2 signaling (R-HSA-1251932) [Homo sapiens]


Activation of PLCG1 signaling is observed only in the presence of ERBB2:EGFR heterodimers, with PLCG1 binding to phosphorylated tyrosine Y992 and Y1173 in the C-tail of EGFR (Chattopadhyay et al. 1999), and potentially Y1023 in the C-tail of ERBB2 (Fazioli et al. 1991, Cohen et al. 1996).

Cross References
Database Identifier
BioModels Database BIOMD0000000175, BIOMD0000000477, BIOMD0000000223, BIOMD0000000019, BIOMD0000000255, BIOMD0000000399, BIOMD0000000427