Reactome: A Curated Pathway Database

PLCG1 events in ERBB2 signaling

Stable Identifier
R-HSA-1251932
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Activation of PLCG1 signaling is observed only in the presence of ERBB2:EGFR heterodimers, with PLCG1 binding to phosphorylated tyrosine Y992 and Y1173 in the C-tail of EGFR (Chattopadhyay et al. 1999), and potentially Y1023 in the C-tail of ERBB2 (Fazioli et al. 1991, Cohen et al. 1996).

Participants
Participant Of
Cross References