Reactome: A Curated Pathway Database

Cleavage of ERBB4m80 by gamma-scretase complex (R-HSA-1251997)

Species Homo sapiens


After ERBB4 is cleaved by ADAM17, gamma-secretase complex performs additional cleavage in the transmembrane region of the m80 ERBB4 fragment, releasing the soluble ERBB4 intracellular domain of 80 kDa, known as s80 or E4ICD.

Locations in the PathwayBrowser
Additional Information
Compartment cytosol , plasma membrane
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
gamma-secretase complex endopeptidase activity (0004175)
Literature References
pubMedId Title Journal Year
11679632 gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase Science 2001