Reactome: A Curated Pathway Database

Cleavage of ERBB4m80 by gamma-scretase complex

Stable Identifier
R-HSA-1251997
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

After ERBB4 is cleaved by ADAM17, gamma-secretase complex performs additional cleavage in the transmembrane region of the m80 ERBB4 fragment, releasing the soluble ERBB4 intracellular domain of 80 kDa, known as s80 or E4ICD.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
endopeptidase activity of gamma-secretase complex [plasma membrane] gamma-secretase complex [plasma membrane] endopeptidase activity (0004175)
Orthologous Events