Reactome: A Curated Pathway Database

Adaptive Immune System (R-HSA-1280218) [Homo sapiens]


Adaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with remarkable diversity tailored to recognize aspects of particular pathogens or antigens. During infection, dendritic cells (DC) which act as sentinels in the peripheral tissues recognize and pick up the pathogen in the form of antigenic determinants and then process these antigens and present them to T cells. These T cells of appropriate specificity respond to the antigen, and either kill the pathogen directly or secrete cytokines that will stimulate B lymphocyte response. B cells provide humoral immunity by secreting antibodies specific for the pathogen or antigen.

Literature References
pubMedId Title Journal Year
21682741 Innate immunity in allergic disease Immunol Rev 2011
16551257 The evolution of adaptive immunity Annu Rev Immunol 2006
11861602 Innate immune recognition Annu Rev Immunol 2002