Spry regulation of FGF signaling

Stable Identifier
R-HSA-1295596
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Pathway
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Homo sapiens
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Sprouty was initially characterized as a negative regulator of FGFR signaling in Drosophila. Human cells contain four genes encoding Sprouty proteins, of which Spry2 is the best studied and most widely expressed. Spry proteins modulate the duration and extent of signaling through the MAPK cascade after FGF stimulation, although the mechanism appears to depend on the particular biological context. Some studies have suggested that Sprouty binds to GRB2 and interferes with the recruitment of GRB2-SOS1 to the receptor, while others have shown that Sprouty interferes with the MAPK cascade at the level of RAF activation. In addition to modulating the MAPK pathway in response to FGF stimulation, Sprouty itself appears to be subject to complex post-translational modification that regulates its activity and stability.

Literature References
PubMed ID Title Journal Year
19570949 Intermolecular interactions of Sprouty proteins and their implications in development and disease

Edwin, F, Anderson, K, Ying, C, Patel, TB

Mol Pharmacol 2009
19690147 Sprouty2 association with B-Raf is regulated by phosphorylation and kinase conformation

Brady, SC, Coleman, ML, Munro, J, Feller, SM, Morrice, NA, Olson, MF

Cancer Res 2009
9458049 sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways

Hacohen, N, Kramer, S, Sutherland, D, Hiromi, Y, Krasnow, MA

Cell 1998
16893902 A Src homology 3-binding sequence on the C terminus of Sprouty2 is necessary for inhibition of the Ras/ERK pathway downstream of fibroblast growth factor receptor stimulation

Lao, DH, Chandramouli, S, Yusoff, P, Fong, CW, Saw, TY, Tai, LP, Yu, CY, Leong, HF, Guy, GR

J Biol Chem 2006
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