Reactome: A Curated Pathway Database

Activation of ATP sensitive Potassium channels in neuroendocrine cells

Stable Identifier
R-HSA-1296024
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

In neuroendocrine cells such as pancreatic alpha-, beta-, and delta-cells and in the brain, ATP sensitive K+ channels assemble as octamers of four Kir 6.1, 6.2 subunits and four high-affinity sulfonyl urea receptor 1 subunits (SUR1). These channels are blocked by excess intracellular levels of ATP. When the ATP is low, ATP dissociates and the channel opens to allow K+ efflux.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
inward rectifier potassium channel activity of ATP sensitive K+ channels-inwardly rectifying (SUR1) [plasma membrane] ATP sensitive K+ channels-inwardly rectifying (SUR1) [plasma membrane] inward rectifier potassium channel activity (0005242)
Orthologous Events