Reactome: A Curated Pathway Database

Activation of ATP sensitive Potassium channels in neuroendocrine cells (R-HSA-1296024)

Species Homo sapiens


In neuroendocrine cells such as pancreatic alpha-, beta-, and delta-cells and in the brain, ATP sensitive K+ channels assemble as octamers of four Kir 6.1, 6.2 subunits and four high-affinity sulfonyl urea receptor 1 subunits (SUR1). These channels are blocked by excess intracellular levels of ATP. When the ATP is low, ATP dissociates and the channel opens to allow K+ efflux.

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Compartment plasma membrane , cytosol , extracellular region
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