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Activation of ATP sensitive Potassium channels in neuroendocrine cells

Stable Identifier
R-HSA-1296024
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

In neuroendocrine cells such as pancreatic alpha-, beta-, and delta-cells and in the brain, ATP sensitive K+ channels assemble as octamers of four Kir 6.1, 6.2 subunits and four high-affinity sulfonyl urea receptor 1 subunits (SUR1). These channels are blocked by excess intracellular levels of ATP. When the ATP is low, ATP dissociates and the channel opens to allow K+ efflux.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
inward rectifier potassium channel activity of ATP sensitive K+ channels-inwardly rectifying (SUR1) [plasma membrane]
Physical Entity
Activity
This entity is regulated by
Orthologous Events
Cross References
Rhea