In neuroendocrine cells such as pancreatic alpha-, beta-, and delta-cells and in the brain, ATP sensitive K+ channels assemble as octamers of four Kir 6.1, 6.2 subunits and four high-affinity sulfonyl urea receptor 1 subunits (SUR1). These channels are blocked by excess intracellular levels of ATP. When the ATP is low, ATP dissociates and the channel opens to allow K+ efflux.
|ATP sensitive K+ channels-inwardly rectifying (SUR1)||inward rectifier potassium channel activity (0005242)|
|18258787||Human hair follicles contain two forms of ATP-sensitive potassium channels, only one of which is sensitive to minoxidil||FASEB J||2008|