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Activation of G protein gated Potassium channels

Stable Identifier
R-HSA-1296041
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Activation of Kir 3 channels occurs after binding of G beta gamma subunits of GPCR. Activation of Kir3/GIRK leads to K+ efflux. The dissociation of GPCR into G alpha and G beta gamma subunits is activated by the activation of GABA B receptor by GABA binding.

Literature References
PubMed ID Title Journal Year
20655490 GABAB-GIRK2-mediated signaling in Down syndrome Adv Pharmacol 2010
Participants
Participant Of
Orthologous Events