Reactome: A Curated Pathway Database

HCN channels (R-HSA-1296061)

Species Homo sapiens


Hyperpolarization-activated and cyclic nucleotide gated (HCN) channel are activated by membrane hyperpolarization and cAMP binding. HCN channels are homotetramers of four subunits HCN1-4. HCN channels conduct Na and K current with a permeability of 1:4. The current flowing through HCN channels is call funny current. HCN channels are involved in controlling the rhythmic activity of pacemaker current in autorythymic cells in heart and neuronal processes such as dendritic integration and synaptic transmission.

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Literature References
pubMedId Title Journal Year
20213494 HCN-related channelopathies Pflugers Arch 2010
19584315 Hyperpolarization-activated cation channels: from genes to function Physiol Rev 2009