Reactome | Inwardly rectifying K+ channels

Inwardly rectifying K+ channels

Stable Identifier

R-HSA-1296065

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Inwardly rectifying K+ channels (Kir channels) show an inward rather than outward (like the voltage gated K+ channels) flow of K+ thereby contributing to maintenance of resting membrane potential and regulation of action potential in excitable tissue. Kir channels are found in a variety of cell types such as cardiac myocytes, neurons, blood cells, osteoblasts, glial cells, epithelial cells, and oocytes. Kir channels can be functionally divided into ATP sensitive K+ channels (Kir 6.1 and Kir 6.2), classical kir channels (Kir 2.1, 2.2, 2.3, 2.4, 5.1) G protein gated K+ channels (Kir 3.1, 3.2, 3.3, 3.4) and K+ transport channels (Kir1.1, 7.1, 4.2, 4.1).

Literature References

PubMed ID	Title	Journal	Year
18087715	Molecular basis for genistein-induced inhibition of Kir2.3 currents Zhao, Z, Jia, Z, Jia, Q, Geng, X, Zhang, G, Liu, B, Zhang, H	Pflugers Arch	2008
18691387	Functional implications for Kir4.1 channels in glial biology: from K+ buffering to cell differentiation Olsen, ML, Sontheimer, H	J Neurochem	2008
20086079	Inwardly rectifying potassium channels: their structure, function, and physiological roles Furutani, K, Findlay, I, Inanobe, A, Hibino, H, Murakami, S, Kurachi, Y	Physiol Rev	2010