Reactome: A Curated Pathway Database

Klotho-mediated ligand binding (R-HSA-1307973)

Species Homo sapiens


The endocrine FGFs (19, 21 and 23) have lower affinity for heparin and HSPG compared to their paracrine or autocrine coutnerparts. Binding of these ligands to their receptors is generally aided by the FGF-binding Klotho proteins.

Additional Information
Compartment cytosol , extracellular region , plasma membrane