Reactome: A Curated Pathway Database

NR1D1 (REV-ERBA) represses gene expression

Stable Identifier
R-HSA-1368071
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

REV-ERBA binds DNA elements very similar to those bound by the transcription activator RORA. RORAREV-ERBA bound to DNA and heme recruits the corepressors NCoR and HDAC3 to repress transcription. Thus REV-ERBA and RORA appear to compete to repress or activate genes, repectively.

Literature References
Participants
Participant Of
hasEvent
Orthologous Events