Reactome: A Curated Pathway Database

BMAL1:CLOCK,NPAS2 activates circadian gene expression

Stable Identifier
R-HSA-1368108
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

As inferred from mouse, BMAL1:CLOCK (ARNTL:CLOCK) and BMAL1:NPAS2 (ARNTL:NPAS2) heterodimers bind to sequence elements (E boxes) in the promoters of target genes and enhance transcription (Gekakis et al. 1998, reviewed in Munoz and Baler 2003).

Literature References
PubMed ID Title Journal Year
Participants
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Participant Of
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Orthologous Events