Reactome: A Curated Pathway Database

BMAL1:CLOCK,NPAS2 activates circadian gene expression (R-HSA-1368108) [Homo sapiens]


As inferred from mouse, BMAL1:CLOCK (ARNTL:CLOCK) and BMAL1:NPAS2 (ARNTL:NPAS2) heterodimers bind to sequence elements (E boxes) in the promoters of target genes and enhance transcription (Gekakis et al. 1998, reviewed in Munoz and Baler 2003).

Additional Information
Compartment nucleoplasm , extracellular region , endoplasmic reticulum lumen , cytosol
Literature References
pubMedId Title Journal Year
12868535 The circadian E-box: when perfect is not good enough Chronobiol Int 2003
9616112 Role of the CLOCK protein in the mammalian circadian mechanism Science 1998