Reactome: A Curated Pathway Database

BMAL1:CLOCK,NPAS2 activates circadian gene expression (R-HSA-1368108)

Species Homo sapiens


As inferred from mouse, BMAL1:CLOCK (ARNTL:CLOCK) and BMAL1:NPAS2 (ARNTL:NPAS2) heterodimers bind to sequence elements (E boxes) in the promoters of target genes and enhance transcription (Gekakis et al. 1998, reviewed in Munoz and Baler 2003).

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm , extracellular region , endoplasmic reticulum lumen , cytosol
Literature References
pubMedId Title Journal Year
12868535 The circadian E-box: when perfect is not good enough Chronobiol Int 2003
9616112 Role of the CLOCK protein in the mammalian circadian mechanism Science 1998