Reactome: A Curated Pathway Database

Activation of ATP sensitive Potassium channels in muscle cells

Stable Identifier
R-HSA-1369017
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

In muscle cells such as cardiac, skeletal, vascular and nonvascular smooth muscle, ATP sensitive K+ channels assemble as octamers of four Kir 6.x subunits and four low-affinity sulfonyl urea receptor 2 subunits (SUR2). The human gene encoding SUR2 gives rise to two splice variants, SUR2A and SUR2B. These channels are blocked by excess intracellular levels of ATP. When the ATP is low, ATP dissociates and the channel opens to allow K+ efflux ().

Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
inward rectifier potassium channel activity of ATP sensitive K+ channels-inwardly rectifying (SUR2) [plasma membrane] ATP sensitive K+ channels-inwardly rectifying (SUR2) [plasma membrane] inward rectifier potassium channel activity (0005242)
Orthologous Events