Reactome: A Curated Pathway Database

ABC transporters in lipid homeostasis

Stable Identifier
R-HSA-1369062
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

A defined subset of the ABC transporter superfamily, the ABCA transporters, are highly expressed in monocytes and macrophages and are regulated by cholesterol flux which may indicate their role in in chronic inflammatory diseases (Schmitz and Kaminski 2001, Schmitz et al. 2000). Some D and G members of the ABC transporter family are also important in lipid transport (Voloshyna & Reiss 2011, Morita & Imanaka 2012, Morita et al. 2011).

Literature References
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Orthologous Events