Reactome: A Curated Pathway Database
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PRLR is phosphorylated at Ser-349

Stable Identifier
R-HSA-1370505
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The PRL responsiveness of target cells is negatively regulated by receptor internalization, ubiquitination and degradation, which limit the duration and intensity of receptor signaling (Djiane et al. 1981, 1982, Lu et al. 2002). The PRLR is phosphorylated on Ser-349 by an unidentified kinase (Li et al. 2006) enabling subsequent recruitment of the SCF beta-TrCP ubiquitin ligase complex (Li et al. 2004).

Literature References
Participants
Participant Of
Orthologous Events