Reactome: A Curated Pathway Database

APP(18-770)

Stable Identifier
R-HSA-139835
Type
Protein
Species
Homo sapiens
Compartment
Synonyms
Amyloid beta A4 protein precursor, APP, ABPP, Alzheimer's disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, Protease nexin-II, PN-II, APPI, PreA4, Soluble APP-alpha, S-APP- alpha, Soluble APP-beta, S-APP-beta, C99, Beta-amyloid protein 42, Beta-APP42, Beta-amyloid protein 40, Beta-APP40, C83, P3(42), P3(40), Gamma-CTF(59), Gamma-secretase C-terminal fragment 59, Amyloid intracellular domain 59, AID(59), Gamma-CTF(57), Gamma- secretase C-terminal fragment 57, Amyloid intracellular domain 57, AID(57), Gamma-CTF(50), Gamma-secretase C-terminal fragment 50, Amyloid intracellular domain 50, AID(50), C31
Locations in the PathwayBrowser
External Reference Information
External Reference
Gene Names
APP, A4, AD1
Chain
signal peptide:1-17, chain:18-770, chain:18-687, chain:18-671, chain:18-286, chain:672-770, chain:672-713, chain:672-711, chain:688-770, peptide:688-713, peptide:688-711, chain:691-770, chain:712-770, chain:714-770, chain:721-770, chain:740-770
Reference Genes
Reference Transcript
Other Identifiers
 0001230601  11738008_s_at  11741216_x_at  11742210_a_at  11742211_x_at
 11742215_s_at  11746866_a_at  11750384_a_at  11751350_a_at  11752199_a_at
 11752200_x_at  11752481_a_at  11762804_x_at  16924551  1AAP
 1AMB  1AMC  1AML  1BA4  1BA6
 1BJB  1BJC  1BRC  1CA0  1HZ3
 1IYT  1MWP  1OWT  1QCM  1QWP
 1QXC  1QYT  1TAW  1TKN  1UO7
 1UO8  1UOA  1UOI  1X11  1Z0Q
 1ZE7  1ZE9  1ZJD  200602_at  211277_3p_x_at
 211277_x_at  214953_s_at  2BEG  2BOM  2BP4
 2FJZ  2FK1  2FK2  2FK3  2FKL
 2FMA  2G47  2IPU  2LFM  2LLM
 2LMN  2LMO  2LMP  2LMQ  2LNQ
 2LOH  2LP1  2LZ3  2LZ4  2M4J
 2M9R  2M9S  2MGT  2MJ1  2MPZ
 2MVX  2MXU  2OTK  2R0W  2WK3
 2Y29  2Y2A  2Y3J  2Y3K  2Y3L
 351  3AYU  3BAE  3BKJ  3DXC
 3DXD  3DXE  3GCI  3IFL  3IFN
 3IFO  3IFP  3JQ5  3JQL  3JTI
 3KTM  3L33  3L81  3MOQ  3MXC
 3MXY  3NYJ  3NYL  3OVJ  3OW9
 3SV1  3U0T  3UMH  3UMI  3UMK
 41136_s_at  4HIX  4JFN  4M1C  4MDR
 4MVI  4MVK  4MVL  4NGE  4OJF
 4ONF  4ONG  4PQD  4PWQ  4XXD
 5AEF  5AM8  5AMB  5CSZ  5HOW
 5HOX  5HOY  64309_f_at  8069644  A0A140VJC8
 A_24_P314159  A_33_P3296479  A_33_P3508822  AAA35540  AAA51564
 AAA51722  AAA51726  AAA51727  AAA51768  AAA58727
 AAA60163  AAB23646  AAB26263  AAB26264  AAB26265
 AAB59501  AAB59502  AAC13654  AAC60601  AAH04369
 AAH65529  AAQ14327  AAW82435  AB066441  AEE60915
 AF282245  AK295621  AK312326  AP001439  AP001440
 AP001441  AP001442  AP001443  APP  APP-001
 APP-002  APP-003  APP-004  APP-016  APP-017
 AY919674  BAA22264  BAB71958  BAG35248  BAG58500
 BC004369  BC065529  CAA30041  CAA30042  CAA30050
 CAA31830  CAA68374  CAB000157  CCDS13576  CCDS13577
 CCDS33523  CCDS46638  CCDS56212  CCDS56213  CH471079
 D87675  EAX09958  EAX09959  EAX09960  EAX09961
 EAX09963  EAX09965  ENSG00000142192  ENSP00000284981  ENSP00000345463
 ENSP00000346129  ENSP00000350578  ENSP00000351796  ENSP00000387483  ENST00000346798
 ENST00000348990  ENST00000354192  ENST00000357903  ENST00000358918  ENST00000440126
 EntrezGene:351  g4502166_3p_at  GE57419  HGNC:620  HM005315
 HPA001462  Hs.177486.2.A1_3p_a_at  Hs.434980  ILMN_1653283  ILMN_1678152
 ILMN_2404063  ILMN_2404065  IPR002223  IPR008154  IPR008155
 IPR011178  IPR013803  IPR015849  IPR019543  IPR019744
 IPR019745  IPR020901  IPR024329  IPR028866  M15532
 M15533  M16765  M18734  M24546  M24547
 M28373  M29269  M29270  M33112  M34862
 M34863  M34864  M34865  M34866  M34867
 M34868  M34869  M34870  M34871  M34872
 M34873  M34874  M34875  M34876  M34877
 M34878  M34879  M35675  M37895  M37896
 MIM:104760  NM_000484  NM_001136016  NM_001136129  NM_001204301
 NM_001204302  NM_001204303  NM_201413  NM_201414  NP_000475
 NP_001129488  NP_001129601  NP_001191230  NP_001191231  NP_001191232
 NP_958816  NP_958817  PF00014  PF02177  PF03494
 PF10515  PF12924  PF12925  PH_hs_0010546  PR00203
 PR00204  PR00759  S45136  S60317  S60721
 S61380  S61383  SM00006  SM00131  uc002ylz.4
 uc002yma.4  uc002ymb.4  uc010glj.4  uc010glk.4  uc021whz.2
 UPI000002A2F2  UPI000002A2F6  UPI000002A2F7  UPI000002DB1C  UPI00001BE539
 UPI00017A7091  X06981  X06982  X06989  X13466
 X13467  X13468  X13469  X13470  X13471
 X13472  X13473  X13474  X13475  X13476
 X13477  X13478  X13479  X13487  X13488
 Y00264  Y00264_at
Participant Of
Other forms of this molecule
Inferred To
Cross References
UCSC human
ZINC_target
GeneCards
PRO
HMDB_protein
Interactors
Confidence Score Interactor Accession Interactor Name Evidence (IntAct)
0.992 P05067 A4_HUMAN 104
0.728 O00213 APBB1_HUMAN 5
0.718 P61812 TGFB2_HUMAN 7
0.663 P10636 TAU_HUMAN 9
0.641 P04156 PRIO_HUMAN 3
0.641 P01137 TGFB1_HUMAN 3
0.633 Q9UQF2 JIP1_HUMAN 4
0.632 P49768 PSN1_HUMAN 6
0.625 Q99714 HCD2_HUMAN 4
0.625 P02647 APOA1_HUMAN 5
0.611 O75509 TNR21_HUMAN 3
0.589 Q9NP59 S40A1_HUMAN 5
0.589 P29353 SHC1_HUMAN 6
0.581 Q13625 ASPP2_HUMAN 3
0.581 O75955 FLOT1_HUMAN 5
0.564 P27797 CALR_HUMAN 2
0.564 Q99683 M3K5_HUMAN 2
0.564 P07196 NFL_HUMAN 2
0.558 P08138 TNR16_HUMAN 2
0.544 Q306T3 Q306T3_9ACTN 3
0.544 P15253 CALR_RABIT 3
0.528 P46933 APBB1_RAT 2
0.524 P01100 FOS_HUMAN 3
0.524 P61457 PHS_HUMAN 2
0.524 Q02410 APBA1_HUMAN 3
0.508 P21359 NF1_HUMAN 3
0.508 Q92870 APBB2_HUMAN 2
0.499 P78352 DLG4_HUMAN 2
0.499 P30101 PDIA3_HUMAN 3
0.489 P56817-1 BACE1 2
0.482 O14879 IFIT3_HUMAN 2
0.463 P36544 ACHA7_HUMAN 2
0.462 P04578 ENV_HV1H2 2