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Activation of BMF and translocation to mitochondria

Stable Identifier
R-HSA-139910
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

In healthy cells, BMF is bound to the myosin V motor complex through its interaction with DLC2. UV irradiation or anoikis induces MAPK8 (JNK) to phosphorylate Dynein Light Chain 2 (DLC2) to release BMF.

Literature References
PubMed ID Title Journal Year
14634621 The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 2003
Participants
Participant Of
Event Information
Orthologous Events