Puma is transactivated in a p53-dependent manner and by E2F1. Activated Puma is translocated to mitochondria.
|GO Biological Process||positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway (1900740)|
|11463392||PUMA, a novel proapoptotic gene, is induced by p53||Mol Cell||2001|
|14684737||Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis||J Biol Chem||2004|