Reactome: A Curated Pathway Database

Activation of PUMA and translocation to mitochondria (R-HSA-139915) [Homo sapiens]


Puma is transactivated in a p53-dependent manner and by E2F1. Activated Puma is translocated to mitochondria.

Literature References
pubMedId Title Journal Year
11463392 PUMA, a novel proapoptotic gene, is induced by p53 Mol Cell 2001
14684737 Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis J Biol Chem 2004