FMO3:FAD N-oxidises TMA
Species Homo sapiens
Trimethylamine (TMA) is present in the diet (in fish) but primarily formed in vivo from the breakdown of choline. It is N-oxidised by FMO3 in the liver, the major isoform active towards TMA Trimethylaminuria (fish-odour syndrome) is a human genetic disorder characterised by an impaired ability to convert the malodourous TMA to its odourless N-oxide (Higgins et al. 1972, Humbert et al. 1970, Treacy et al. 1998).
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