Reactome: A Curated Pathway Database

FMO3:FAD N-oxidises TMA (R-HSA-139970)

Species Homo sapiens


Trimethylamine (TMA) is present in the diet (in fish) but primarily formed in vivo from the breakdown of choline. It is N-oxidised by FMO3 in the liver, the major isoform active towards TMA Trimethylaminuria (fish-odour syndrome) is a human genetic disorder characterised by an impaired ability to convert the malodourous TMA to its odourless N-oxide (Higgins et al. 1972, Humbert et al. 1970, Treacy et al. 1998).

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Additional Information
Compartment endoplasmic reticulum lumen , endoplasmic reticulum membrane
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
FMO3:FAD N,N-dimethylaniline monooxygenase activity (0004499)
Cross References
Database Identifier
Rhea 31982, 31980