Reactome: A Curated Pathway Database

Apoptosis induced DNA fragmentation

Stable Identifier
R-HSA-140342
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

DNA fragmentation in response to apoptotic signals is achieved through the activity of two apoptotic nucleases, termed DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease G (Endo G) (reviewed in Widlak and Garrard, 2005). These endonucleases cleave chromatin producing 3'-hydroxyl groups and 5'-phosphate residues. 50-300 kb cleavage products are produced followed by internucleosomal DNA fragmentation. Although the activities of DFF and Endo G are similar, they reside in different locations within the cell and are regulated in different ways.

Literature References
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Orthologous Events