Reactome: A Curated Pathway Database

Arachidonic acid is oxidised to PGG2 by PTGS1

Stable Identifier
R-HSA-140355
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Arachidonic acid oxidised to PGG2
Locations in the PathwayBrowser
Summation

Prostaglandin G/H synthase PTGS1 exhibits a dual catalytic activity, a cyclooxygenase and a peroxidase. The cyclooxygenase function catalyzes the initial conversion of arachidonic acid to an intermediate, prostaglandin G2 (PGG2) (Hamberg et al. 1974, Nugteren 1973).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
prostaglandin-endoperoxide synthase activity of PTGS1 dimer [endoplasmic reticulum membrane] PTGS1 dimer [endoplasmic reticulum membrane] prostaglandin-endoperoxide synthase activity (0004666)
Orthologous Events
Cross References
Rhea