Reactome: A Curated Pathway Database

Arachidonic acid is oxidised to PGG2 by PTGS1 (R-HSA-140355)

Species Homo sapiens


Prostaglandin G/H synthase PTGS1 exhibits a dual catalytic activity, a cyclooxygenase and a peroxidase. The cyclooxygenase function catalyzes the initial conversion of arachidonic acid to an intermediate, prostaglandin G2 (PGG2) (Hamberg et al. 1974, Nugteren 1973).

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Additional Information
Compartment endoplasmic reticulum lumen , endoplasmic reticulum membrane
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Catalyst Activity
PhysicalEntity Activity Active Units
PTGS1 dimer prostaglandin-endoperoxide synthase activity (0004666)
Cross References
Database Identifier
Rhea 42597
Literature References
pubMedId Title Journal Year
4521806 Isolation and structure of two prostaglandin endoperoxides that cause platelet aggregation Proc Natl Acad Sci U S A 1974
4776443 Isolation and properties of intermediates in prostaglandin biosynthesis Biochim Biophys Acta 1973