Reactome: A Curated Pathway Database

PGG2 is reduced to PGH2 by PTGS1

Stable Identifier
R-HSA-140359
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Peroxidative reduction of PGG2 to PGH2
Locations in the PathwayBrowser
Summation

Prostaglandin G/H synthase 1 (PTGS1) exhibits a dual catalytic activity, a cyclooxygenase and a peroxidase. The peroxidase function converts prostaglandin G2 (PGG2) to prostaglandin H2 (PGH2) via a two-electron reduction (Hamberg et al. 1973, Hla & Neilson 1992, Swinney et al. 1997, Barnett et al. 1994).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
peroxidase activity of PTGS1 dimer [endoplasmic reticulum membrane] PTGS1 dimer [endoplasmic reticulum membrane] peroxidase activity (0004601)
Orthologous Events