Reactome: A Curated Pathway Database

PGG2 is reduced to PGH2 by PTGS1 (R-HSA-140359)

Species Homo sapiens


Prostaglandin G/H synthase 1 (PTGS1) exhibits a dual catalytic activity, a cyclooxygenase and a peroxidase. The peroxidase function converts prostaglandin G2 (PGG2) to prostaglandin H2 (PGH2) via a two-electron reduction (Hamberg et al. 1973, Hla & Neilson 1992, Swinney et al. 1997, Barnett et al. 1994).

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Additional Information
Compartment endoplasmic reticulum lumen , endoplasmic reticulum membrane
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Catalyst Activity
PhysicalEntity Activity Active Units
PTGS1 dimer peroxidase activity (0004601)