Reactome: A Curated Pathway Database

prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (R-HSA-140664) [Homo sapiens]


The membrane-bound Va:Xa (prothrombinase) complex rapidly activates large amounts of thrombin.

Additional Information
Compartment extracellular region , plasma membrane
Catalyst Activity
PhysicalEntity Activity Active Units
Va:Xa complex (prothrombinase) serine-type endopeptidase activity (0004252)  
Literature References
pubMedId Title Journal Year
3052293 Cofactor proteins in the assembly and expression of blood clotting enzyme complexes Annu Rev Biochem 1988
14982929 The factor V activation paradox J Biol Chem 2004