Reactome: A Curated Pathway Database
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factor Va + factor Xa -> Va:Xa complex (prothrombinase)

Stable Identifier
R-HSA-140686
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Factors Va and Xa associate on a membrane surface to form a complex in which the activity of factor Xa on prothrombin is greatly increased (Mann et al. 1988). The presence of negatively charged phospholipid in the membrane greatly facilitates this process, a feature that may contribute to its localization, as such phospholipids are normally on the cytosolic face of the plasma membrane (Devaux 1992), but could be exposed to the extracellular space following platelet activation or mechanical injury to endothelial cells.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
Orthologous Events