Reactome: A Curated Pathway Database

factor Va + factor Xa -> Va:Xa complex (prothrombinase) (R-HSA-140686)

Species Homo sapiens


Factors Va and Xa associate on a membrane surface to form a complex in which the activity of factor Xa on prothrombin is greatly increased (Mann et al. 1988). The presence of negatively charged phospholipid in the membrane greatly facilitates this process, a feature that may contribute to its localization, as such phospholipids are normally on the cytosolic face of the plasma membrane (Devaux 1992), but could be exposed to the extracellular space following platelet activation or mechanical injury to endothelial cells.

Locations in the PathwayBrowser
Additional Information
Compartment extracellular region , plasma membrane
Literature References
pubMedId Title Journal Year
3052293 Cofactor proteins in the assembly and expression of blood clotting enzyme complexes Annu Rev Biochem 1988