Reactome: A Curated Pathway Database

antithrombin III + heparin -> antithrombin III:heparin (R-HSA-140806) [Homo sapiens]


Antithrombin III binds to membrane-associated heparin, e.g., on the surface of a normal endothelial cell. This binding event increases the affinity of antithrombin III for thrombin approximately 1000-fold.

Additional Information
Compartment extracellular region , plasma membrane
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Literature References
pubMedId Title Journal Year
12907439 Heparin-induced substrate behavior of antithrombin Cambridge II Blood 2003