antithrombin III + heparin -> antithrombin III:heparin

Stable Identifier
R-HSA-140806
Type
Reaction
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Locations in the PathwayBrowser
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Summation

Antithrombin III binds to membrane-associated heparin, e.g., on the surface of a normal endothelial cell. This binding event increases the affinity of antithrombin III for thrombin approximately 1000-fold.

Literature References
PubMed ID Title Journal Year
12907439 Heparin-induced substrate behavior of antithrombin Cambridge II Blood 2003
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
antithrombin III + heparin -> antithrombin III:heparin (Arabidopsis thaliana)
antithrombin III + heparin -> antithrombin III:heparin (Bos taurus)
antithrombin III + heparin -> antithrombin III:heparin (Canis familiaris)
antithrombin III + heparin -> antithrombin III:heparin (Danio rerio)
antithrombin III + heparin -> antithrombin III:heparin (Drosophila melanogaster)
antithrombin III + heparin -> antithrombin III:heparin (Gallus gallus)
antithrombin III + heparin -> antithrombin III:heparin (Mus musculus)
antithrombin III + heparin -> antithrombin III:heparin (Oryza sativa)
antithrombin III + heparin -> antithrombin III:heparin (Rattus norvegicus)
antithrombin III + heparin -> antithrombin III:heparin (Sus scrofa)
antithrombin III + heparin -> antithrombin III:heparin (Taeniopygia guttata)
antithrombin III + heparin -> antithrombin III:heparin (Xenopus tropicalis)