Reactome | antithrombin III + heparin -> antithrombin III:heparin

antithrombin III + heparin -> antithrombin III:heparin

Stable Identifier

R-HSA-140806

Type

Reaction

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Locations in the PathwayBrowser

Summation

Antithrombin III binds to membrane-associated heparin, e.g., on the surface of a normal endothelial cell. This binding event increases the affinity of antithrombin III for thrombin approximately 1000-fold.

Literature References

12907439

Heparin-induced substrate behavior of antithrombin Cambridge II

Blood

2003

Participants

input

Heparin [plasma membrane]
SERPINC1 [extracellular region] (Homo sapiens)

output

antithrombin III:heparin [plasma membrane] (Homo sapiens)

Participant Of

hasEvent

Common Pathway of Fibrin Clot Formation

Orthologous Events

antithrombin III + heparin -> antithrombin III:heparin (Xenopus tropicalis)
antithrombin III + heparin -> antithrombin III:heparin (Sus scrofa)
antithrombin III + heparin -> antithrombin III:heparin (Mus musculus)
antithrombin III + heparin -> antithrombin III:heparin (Drosophila melanogaster)
antithrombin III + heparin -> antithrombin III:heparin (Canis familiaris)
antithrombin III + heparin -> antithrombin III:heparin (Gallus gallus)
antithrombin III + heparin -> antithrombin III:heparin (Taeniopygia guttata)
antithrombin III + heparin -> antithrombin III:heparin (Bos taurus)
antithrombin III + heparin -> antithrombin III:heparin (Rattus norvegicus)
antithrombin III + heparin -> antithrombin III:heparin (Danio rerio)